Interestingly, in a study by Duijkers et al.,39AXL overexpression was observed in established human NB cell lines that had not been exposed to targeted therapy, and its genetic depletion led to decreased cell migration and invasion, but not proliferation or downstream signaling.39 The decreased growth kinetics and downregulated pERK after AXL depletion in the TAE684-resistant cells likely reflect their relatively higher dependence on increased AXL activity. This evidence concerns the gene AXL and neuroblastoma.