This is the case, for example, for meQTLs in genes such as IGF2BP2, HOXC6 and ZNF492 (Fig. 3c–e), which have been associated with height, age at menarche, type-2 diabetes, bone mineral density and gene–diet interactions48, 49, 50, 51, 52. This evidence concerns the gene ZNF492 and type 2 diabetes mellitus.