Patients with lamin A/C mutations initially have no overt cardiac disease or symptoms, but go on to develop AV conduction defects, sinus bradycardia and atrial arrhythmias before their fourth decade of life, followed by the development of dilated cardiomyopathy and sudden cardiac death in their fourth to fifth decades of life5. The gene discussed is LMNA; the disease is Sinus bradycardia.