Hyperglycemia in LIRKO mice is characterized by unsuppressed hepatic gluconeogenesis associated with increased mRNA expressions of two gluconeogenesis enzymes, Pck1 and G6pc. Although Pck1 expression was only mildly elevated, G6pc expression was markedly elevated in InsrP1195L/+/HFD mice. Here, PCK1 is linked to Hyperglycemia.