PLCB1 and central nervous system cancer: Nucleus presence of PLCβ1 was demonstrated in cortical neurons of rabbit brain [15, 47], and evidence demonstrated that two isoforms have their preference in the cytosol and nuclear of C6 glioma cells, respectively [23]; PLCβ1 was also shown to be transited into the nucleus among C6 glial cell and Neuro2A cell (mouse neuroblastoma cell line) under stimuli [48].