PLCB1 and poikiloderma with neutropenia: We analyzed four independent microarray datasets from the NIH-maintained GEO databases, REMBRANDT, and the TCGA database and found that PLCβ1 gene expression (microarray and RNA-Seq) level is inversely correlated with gliomas’ pathological grades; it is a potential novel signature gene in subclassifying HGG into PN versus other subtypes, and its expression level also correlates with patients’ survival.