Interestingly, a Kaplan-Meier survival curve demonstrates statistical significance among the stratified groups based on PLCβ1 expression in glioma and its subclass astrocytoma, while a Kaplan-Meier survival curve based on different ERBB4 expression levels only shows statistical significance among stratified glioma cases, but fails to show statistical significance among astrocytoma cases (Supplement S4). This evidence concerns the gene ERBB4 and astrocytoma (excluding glioblastoma).