THBD and diabetes mellitus: As little literature data are available concerning coagulation factors in depressed subjects with diabetes, the aims of the study were twofold: First, evaluate levels of plasma thrombomodulin, PAI-1 and fibrinogen in elderly patients with T2DM with and without depressive symptoms and second, identify the factors (including thrombomodulin, PAI-1 and fibrinogen levels) associated with depressive symptoms in elderly patients with T2DM.