Most abundant mutations in cancer are frameshifts at positions K390 and K462 (4%), followed by missense mutations (S684L, S715L, S716L or G359D from 2–1%) although the latter ones are mostly distributed in the T-loop insert, in which changes in amino acid sequence do not affect GWL activity (Vigneron et al., 2011). Here, MASTL is linked to cancer.