To investigate whether GWL overexpression/hyperactivation influences tumour growth in vivo, we injected MDA-MB-231 cells stably transfected with empty vector (CT) or WT GWL or D3H2LN cells that stably express control shRNA (SH LUC) or GWL shRNA (SH GWL) in athymic nude mice and monitored tumour growth regularly. Here, MASTL is linked to neoplasm.