CLCA1 is a promising therapeutic target for asthma and COPD, as it is the only member of its family to be upregulated in models of IL-13 mediated mucus overproduction [9], is a secreted protein [18], is expressed in goblet cells [7, 9, 16], and associates with mucin granules [46, 47]. Here, CLCA1 is linked to chronic obstructive pulmonary disease.