CCM is caused by the loss‐of‐function mutations of any of three independent genes, known as CCM1, CCM2, and CCM3. We have recently reported that the TGFβ/BMP signaling pathway induces an endothelial‐to‐mesenchymal transition (EndMT) in Ccm‐deficient ECs that, in turn, contributes to the development and progression of cavernomas. This evidence concerns the gene PDCD10 and cerebral cavernous malformation.