Moreover, since several signaling pathways are reported to contribute to CCM, it would interesting to investigate whether other transcription factors could have a crosstalk with the MEKK3‐MEK5‐ERK5‐MEF2‐KLF4 axis during the development and progression of cavernomas (Goitre et al, 2010; Stockton et al, 2010; Faurobert et al, 2013; Bravi et al, 2015; Gibson et al, 2015). This evidence concerns the gene KLF4 and cavernous hemangioma.