We report here an accumulation model of 8 common single nucleotide polymorphisms from the “broader fragile X family” (FMR1, FXR1, FXR2, FMR2) that yields significant association with autistic traits in a discovery sample of male patients with schizophrenia (N = 692) and in three independent male replicate samples: (I) Patients with schizophrenia from Munich/Halle (N = 626), (II) patients with psychiatric diagnoses other than schizophrenia (extended GRAS data collection; N = 111), and (III) a general population sample from Greifswald (N = 2,005). This evidence concerns the gene FMR1 and schizophrenia.