A lack of oligodendroglial accumulation of phosphorylated alpha-synuclein has also been observed in M83+/−-mice injected with brain homogenates from MSA patients and it was speculated that the lack of alpha-synuclein aggregation in oligodendrocytes might be due to poor transgene expression in these cells [39, 61]. This evidence concerns the gene PGAP6 and multiple system atrophy.