Interestingly, punctate aggregates of phosphorylated alpha-synuclein in the brains of Tg(SNCA)1Nbm/J mice injected with brains extracts from patients with MSA or iLBD colocalized with ubiquitin and p62 as has been observed in earlier transmission studies to other mouse models of synucleinopathies [31, 45–48]. This evidence concerns the gene SNCA and multiple system atrophy.