SNCA and synucleinopathy: In this study, all Tg(SNCA)1Nbm/J mice injected with patient brain extracts developed synucleinopathy that efficiently spread to the contralateral hemisphere within 9 months post injection suggesting that sequence identity between the alpha-synuclein seeds from human brain extracts and human wild-type alpha-synuclein expressed in these mice and possibly also the lack of endogenously expressed mouse alpha-synuclein facilitated the prion-like spread.