SNCA and Parkinson disease: Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) are part of a spectrum of neurodegenerative disorders characterized by accumulation of misfolded alpha-synuclein, preferentially in cells of the nervous system, and are therefore often conceptualized as synucleinopathies [52, 53, 60].