Upregulation of miR-221/-222 in PCa suggest a mechanistic link to PCa since miR-221/-222 plays a role in AR pathway regulation, c-kit, PTEN, and TIMP3 et al. miR-124 was characterized to have a direct targeting of AR thereby inducing down-regulation of miR-125b and up-regulation of p53. The gene discussed is TIMP3; the disease is posterior cortical atrophy.