Significant association for TGFB3 rs3917158 SNP could also be observed for that subgroup analysis (p < 0.05 for dominant model and increased frequency of heterozygotes among infertile men with semen abnormalities, p = 0.056 for differences in minor allele frequency) (Supplementary Table 1). The gene discussed is TGFB3; the disease is Infertility.