Moreover, we also tested both a phosphatase dead (C459G) and an activating (Noonan syndrome-causing, D61G) mutation of SHP2 (gene ID PTPN11) using Donor D2.1 (pMDS-GOI-TETon-3G) in HEK293 cells that stably express the growth hormone (GH) receptor23. The gene discussed is PTPN11; the disease is Noonan syndrome.