On the other hand, Bnip3 expression can be silenced in leukaemias [152] and pancreatic [153], colorectal and gastric [154] cancers, and lost Bnip3 [153] or high AMBRA1 [155] expression in pancreatic cancer correlate with worsened prognosis. This evidence concerns the gene BNIP3 and familial pancreatic carcinoma.