INS and neoplasm: Fusicoccane diterpenoids exhibit diverse biological activities, such as plant growth regulating activity (fusicoccins)30, lysophospholipase inhibitory activity (cyclooctatin)31, antimicrobial activity (periconicins)32, 33, nitrification inhibitory activity (brachialactone)34, cytotoxicity against tumor cells (cotylenins)35, inhibiting insulin-stimulated GLUT4 fusion activity (fusicoccins)35, and so on.