Considering that the S. suis P1/7 hyaluronate lyase (truncated and inactive form) has been shown to interact with an angiogenin inhibitor [25], it can be suggested that the highly conserved 2 bp insertion in the hyaluronate lyase gene could lead to more invasive isolates by enhancing vascular permeability of the blood–brain barrier leading to the development of meningitis. This evidence concerns the gene ANG and infectious meningitis.