Compared with the gAD + I/R group, the infarct volume in mice pretreated with AdipoR1 siRNA was significantly increased 24 h after I/R in T1DM-8W mice (14.7% ± 4.3% vs. 31.2% ± 5.8%, P = 0.038, gAD + I/R vs. siRNA + gAD + I/R). The gene discussed is ADIPOR1; the disease is type 1 diabetes mellitus.