We found a significant reduction in several SNARE-complex forming presynaptic proteins including, but not limited to a 59 % reduction in SNAP-25 levels, 41 % reduction in synaptobrevin/VAMP2 levels and a 43 % reduction in syntaxin 1 levels in brains of terminal AD-ANCL patients compared to controls. Here, VAMP2 is linked to Alzheimer disease.