ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In human ADIPOQ, intron 2 variation (rs17366743: c.214+276A/C) has been linked with promoter polymorphisms in the gene, including c.-11426A/G, c.-11377C/G and c.-11391G/A, and is associated with ADIPOQ levels in diabetes and obesity [20].