INS and type 2 diabetes mellitus: While meta-analyses detect little or no impact of marine derived omega-3 PUFAs on insulin sensitivity or reduction in risk of developing T2D there are a number of human, animal and cell studies which support a potential role of omega-3 PUFAs in the treatment of IR/T2D through alterations in muscle metabolism, and omega-3 PUFAs may protect against some of the metabolic defects induced by a high fat diet [100,123,124,125].