In a progressive chronic renal diseases and kidney fibrosis mouse model (UUO), it was further validated that there was a potential common pathway contributing to tubulointeritial fibrosis and Epithelial-Mesenchymal Transition which included TGFβ signaling activation, ectopic microRNAs expression, and BMP7 signaling blockage [1,2,3,6,42,43,44,45]. The gene discussed is TGFB1; the disease is chronic kidney disease.