These studies identified seven independent glioma risk loci in six chromosomal regions: 5p13.33 (TERT), 7p11.2 (EGFR, two loci), 8q24.21 (CCDC26), 9p21.3 (CDKN2A/B), 11q23.3 (PHLDB1) and 20q13.33 (RTEL1)3, 4, 5, 6, 7, 8, 9. The gene discussed is PHLDB1; the disease is central nervous system cancer.