The results showed that miR-22 appeared to be elevated in human MDS and leukemia and its deregulation expression correlated with poor survival of patients and TET2 downregulation.40 MiR-22 exhibits complex dysregulation in different circumstances and different subcellular distributions, therefore, miR-22 expression may be oppositely changed in the progressions of different tumors. The gene discussed is TET2; the disease is leukemia.