BCL2 and neoplasm: We recently investigated anti-apoptotic Bcl-2 proteins to evaluate a strategy to induce apoptosis in a tumor-specific way and observed that – in contrast to tumor cells – targeting of a single anti-apoptotic Bcl-2 protein by RNAi does not affect survival of primary (non-transformed) human fibroblasts.15 To understand whether any anti-apoptotic proteins are required for survival we analysed the effect of combined simultaneous RNAi to two anti-apoptotic Bcl-2 proteins.