Recently, several autoimmune diseases, including the Aicardi-Goutières and Singleton-Merten syndromes, have been linked to RLRs through whole exome sequencing, which discovered single amino acid mutations that are mostly found within the ATPase domain of RLRs (Jang et al., 2015; Rice et al., 2014; Rutsch et al., 2015). Here, DNAH8 is linked to autoimmune disease.