For the both up-regulated adenosine monophosphate deaminase 2 (Ampd2) and adenosine deaminase (Adat2) in groups with obesity, a recent review suggested that there may be a closer interaction between the inflammatory events and obesity [50], indicating possible different mechanisms in obese mouse compared to the acute lung injury observed after smoke exposure in regular weight mice. The gene discussed is ADAT2; the disease is obesity due to melanocortin 4 receptor deficiency.