The present study demonstrated that lutein and zeaxanthin inhibited the secretion of IL-8 induced by LPS through the activation of JNK1/2 and NF-κB signal pathway, but not p38 and ERK pathway; this is consistent with the animal study, which showed that lutein inhibited the activation of NF-κB in the iris-ciliary body in LPS-induced uveitis and in cultured macrophages [9, 10]. The gene discussed is MAPK8; the disease is uveitis.