Based on the current LOVD databases (www.ucl.ac.uk/ldlr/LOVDv.1.1.0/ and https://grenada.lumc.nl/LOVD2/UCLHeart/home.php?select_db=LDLR), there are more than 1700 mutations in the LDLR gene worldwide, reflecting the extensive genetic heterogeneity of FH patients, especially among different races. This evidence concerns the gene LDLR and familial hyperaldosteronism.