Voutetakis at al. also reported on a neonate with a novel PROP1 gene mutation (Q83X) coexisting with previously described 296delGA which led to protein truncation (the protein product was restricted to only 82 of the 226 amino acids) and, therefore, absence of the DNA-binding and transactivation domain of PROP1. A child affected by these mutations presented prolonged jaundice, early manifested central hypothyroidism and pituitary enlargement (Voutetakis et al. 2004b). Here, PROP1 is linked to Central hypothyroidism.