BRCA2 and breast cancer: Only one interpretation of this report was allowed in the questionnaire and the response option most consistent with a VUS was “a gene mutation found but unknown if causing her breast cancer.” A clear majority (83.9 %) chose this response, only 13.6 % responded they “didn’t know” and there were no responses that either a pathogenic BRCA2 mutation was found or that no pathogenic mutation was found (Table 2).