APP and amyloidosis: We also crossed PS1∆exon8 with the previously described FAD Dutch APP mice16, and we found that double heterozygous mice (i.e., FAD Dutch APP +/− X PS1∆exon8 +/− mice) displayed no exacerbation of the behavioral deficits, or the vascular and parenchymal amyloid pathology in the FAD Dutch APP mice.