Hence, this study aimed to investigate the expression of glycometabolism- and lipid metabolism-related proteins in breast carcinoma, including CYP27A1, CYP7B1, insulin-like growth factor-1 (IGF-1), glucose-6-phosphate-dehydrogenase (G6PD), glutathione S-transferase P1 (GSTP1), and pyruvate kinase isoform M2 (PKM2), and to evaluate their significance in the prognosis of this disease. This evidence concerns the gene PKM and breast carcinoma.