In the present study, we conducted a retrospective analysis on the expression of CYP27A1, CYP7B1, IGF-1, G6PD, GFPT1, and PKM2 proteins in cancer tissues from 20 cases of primary breast carcinoma, among whom 10 cases were diagnosed with recurrent metastasis and 10 cases had no evidence of recurrence or metastasis during their follow-up. The gene discussed is GFPT1; the disease is cancer.