Multivariate survival analysis indicated that only G6PD expression (hazard ratio = 13.488, P = 0.021) was an independent prognostic factor for mean PFS time (Table 4), suggesting that the primary breast carcinoma patients with upregulated G6PD expression were more likely to have poor PFS survival due to local recurrence or metastasis. This evidence concerns the gene G6PD and breast carcinoma.