However, its prognostic role depends on the subcellular localization, the p53-mediated nuclear positivity usually indicating a more aggressive behavior, a higher risk for tumor relapse and lymph node metastases, whereas loss of expression proved to induce a higher risk for distant metastases, at least for gastrointestinal malignant tumors [30, 31]. The gene discussed is TP53; the disease is metastatic malignant neoplasm in the lymph nodes.