MAPK8 and neoplasm: Similarly, overexpression of a dominant-negative form of basket, which decreases Jnk signaling and slows down stem cell proliferation rates (Biteau et al., 2010), decreased the percentage of male midguts with neoplasia from 13.3% in controls (n = 330) to 5.5% in induced flies (n = 308, Figure 3D).