Enrichment of SSEA4-positive cells in residual tumors of all the tumor models used in this study suggests that this pluripotency marker overcomes the heterogeneity shown by many cancer stem markers analyzed (e.g., CD44, CD133, CD117, CD271, ABCG2) [27–29] that were found to be enriched only in single models. The gene discussed is KIT; the disease is cancer.