MBTPS1 and cancer: These sphingolipid metabolites are involved in diverse cellular processes25 as well as cancer pathogenesis and treatment.26 We have previously determined their differential effects on the biomechanical properties of cells as they transition to cancer.27 S1P is a ubiquitous signaling molecule that acts as a ligand for five G-protein coupled receptors (S1P1-5) whose downstream effects are implicated in a variety of important pathologies including cancer, inflammation, and fibrosis.