Subsequently, non-significant increases in [TIMP-2]•[IGFBP7] were found for typical HUS (P = 0.51), hypovolemia/dehydration, interstitial nephritis, nephrotoxic AKI, renal vein thrombosis, perinatal asphyxia and vasculitis. The gene discussed is IGFBP7; the disease is interstitial nephritis.