In a proteomic approach in a small cohort of critically ill adult patients, IGFBP7 and neutrophil gelatinase-associated lipocalin (NGAL) were identified as best predictors of renal recovery; subsequent validation confirmed the prognostic value of IGFBP7 and NGAL in predicting mortality (IGFBP7: AUC 0.68; NGAL: AUC 0.81), recovery (IGFBP7: AUC 0.74; NGAL: AUC 0.70) and severity of AKI (IGFBP7: AUC 0.77; NGAL: AUC 0.69) [34]. The gene discussed is LCN2; the disease is acute kidney injury.