Subsequently, non-significant increases in [TIMP-2]•[IGFBP7] were found for typical HUS (P = 0.51), hypovolemia/dehydration, interstitial nephritis, nephrotoxic AKI, renal vein thrombosis, perinatal asphyxia and vasculitis. This evidence concerns the gene IGFBP7 and hemolytic-uremic syndrome.