Our data demonstrate that an once-only urinary [TIMP-2]•[IGFBP7] measurement is a good predictor for 30 day- (AUC 0.79) and 3 month-mortality (AUC 0.84) and a fair predictor for RRT (AUC 0.67) in a heterogeneous neonatal and pediatric cohort of established primary and secondary AKI according to pRIFLE criteria. Here, IGFBP7 is linked to acute kidney injury.