ROC curve analysis of [TIMP-2]•[IGFBP7] for the assessment of AKI severity revealed an AUC of 0.75 (95% CI: 0.65–0.85) for the pRIFLE stage “Injury” and higher and an AUC of 0.74 (95% CI: 0.64–0.83) for any pRIFLE stage. This evidence concerns the gene TIMP2 and acute kidney injury.