In conclusion, the lack of an induction of IFNL3 by HCV in the liver of patients with chronic hepatitis C, the lack of an attenuation of basal IFNL3 transcript expression in IFNL3 rs4803217 or IFNL4 rs368234815 minor allele carriers, and the lack of an induction of myosin genes and their corresponding myomiRs argue against IFNL3 rs4803217 or IFNL4 rs368234815 variations to be causally related to clearance of HCV infection by modulating hepatic IFNL3 expression. This evidence concerns the gene IFNL4 and chronic hepatitis C virus infection.