MAPK1 and familial pancreatic carcinoma: A mean increase to 190.19% of activated ERK in pancreatic cancer MIA PaCa cells (175.32%–204.08%; p = 0.0036; n = 3), and 160.23% in colon cancer HCT116 cells (144.99%–174.22%; p = 0.012; n = 3) were observed after treatment with flavone B (Fig 3B and 3D) as compared to controls.