A significant decrease of phosphorylated BAD at serine 112 is observed in pancreatic cancer Panc 28 and colon cancer CaCo-2 cells after treatment with flavone A. The activation of BAD at serine 112 is mediated by the MAPK pathway, specifically via the activation of Ras-Raf-ERK [35]. The gene discussed is MAPK1; the disease is familial pancreatic carcinoma.