Soon after the detrimental effects of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine on motor function were described and the inhibitory action of the toxin against respiratory chain complex I (CI) was unraveled,3 isolated CI deficiency was discovered in homogenates from postmortem SN samples of PD patients.4 The importance of this finding was emphasized when familial PD cases were found to harbor mutations in proteins involved in the removal of damaged mitochondria or the scavenging of reactive oxygen species that are predominantly generated by the electron transport chain.5 Here, NDUFB6 is linked to Parkinson disease.