Our data further support these observations because although glucocorticosteroids have a clear anti-asthmatic effect (Fig 1C), LABAs activate STAT6 even in the presence of glucocorticosteroids and are alone sufficient to induce asthma-like airway obstruction in the complete absence of allergen provocation (Fig 1D and 1H; S3 Fig). This evidence concerns the gene STAT6 and Airway obstruction.