The tear chemokines which have been implicated in dry eye are CX3CL1 [64], CXCL10 [64], CCL4/MIP-1beta [124],[125], CCL3/MIP-1alpha [57],[125],[126], CCL5/RANTES [57], CXCL9, -10, and -11 [127]. The gene discussed is CCL5; the disease is Keratoconjunctivitis sicca.