TNFRSF12A and cancer: While overexpression of IL-17RC has been implicated in Bcl-2- and Bcl-XL-independent protection of cancer cell lines from TNFα-induced apoptosis [15], TWEAKR signaling has been shown to enhance the expression of NFκB (nuclear factor kappa-light-chain-enhancer of activated B-cells)-regulated genes including IL-6, IL-8, RANTES, and ICAM-1 (CD54) [16].