Furthermore, the expression of all well-established costimulatory molecules, including CD40, CD54, CD80, CD83, CD86, 4-1BB, GITR (glucocorticoid-induced TNFR-related protein), OX40L, and SLAM (signaling lymphocytic activation molecule), was downregulated in DC-tumor fusion cells. This evidence concerns the gene ICAM1 and neoplasm.