MTOR and neoplasm: The PI3K/Akt/mTOR pathway has been shown to play a critical role in cell proliferation, survival, and metastasis of cancer cells [48], and we observed that inhibition of the PI3K/Akt and inhibition of the mTOR pathway enhanced the immune-stimulatory capacity of DC-tumor fusions through induction of bioactive IL-12p70 secretion.