Consistent with Wunderlich’s observations, in another study, using a double knockout of Cav-1 and eNOS (Cav-1/eNOS KO), Zhao et al. [51] have shown that Cav-1/eNOS KO mice did not develop pulmonary hypertension and the ratio of right ventricle weight/left ventricle plus septum weight was normalized in Cav-1/eNOS KO mice. The gene discussed is NOS3; the disease is pulmonary arterial hypertension.