In addition, three independent studies that used in vivo models of tumor-induced angiogenesis involving mouse B16 melanoma cells implanted in Cav-1 KO and WT C57BL/6 mice [118,119] and RM-9 prostate cancer cells or human prostate cancer LNCaP cells implanted into nude mice [120], have determined that Cav-1 plays a pro-angiogenic role in tumor-induced angiogenesis. The gene discussed is CAV1; the disease is prostate carcinoma.