CAV1 and hepatocellular carcinoma: Using dual-label immunofluorescence staining with Cav-1 and CD34 antibodies in hepatocellular carcinoma sections Zhang et al. [129] showed a positive correlation between Cav-1 expression and microvascular density, implying that Cav-1 plays a positive role in regulating hepatic cell carcinoma tumor-induced angiogenesis in humans.