Although ventricular cardiomyocytes express primarily Cav-3, surprisingly numerous studies have reported cardiomyopathy in Cav-1 KO mice [76,78,87,88] For example, Cohen et al. [87] have shown that Cav-1 KO mice develop progressive concentric left ventricular hypertrophy, as well as right ventricular dilation. Here, CAV1 is linked to Vascular dilatation.