SMPD1 and Stroke: We found an effect of fluoxetine on stroke/glial scar size at day 28 (1.047 mm2 ± 0.33 versus 2.778 mm2 ± 0.55, p < 0.0001, n = 10; Figure 5(a)) but could not observe any effect of fluoxetine on total ceramide levels (Figure 5(d)) and ASM activity (Figure 5(e)) and most importantly on functional outcome (Figure 5(b)).