We found an effect of fluoxetine on stroke/glial scar size at day 28 (1.047 mm2 ± 0.33 versus 2.778 mm2 ± 0.55, p < 0.0001, n = 10; Figure 5(a)) but could not observe any effect of fluoxetine on total ceramide levels (Figure 5(d)) and ASM activity (Figure 5(e)) and most importantly on functional outcome (Figure 5(b)). Here, SMPD1 is linked to stroke disorder.