IL1B and encephalomyelitis: Particularly, Yoon et al. reported that water extract of Scutellariae Radix inhibits the production of NO and synthesis of IL-6 and IL-10 in the LPS-stimulated macrophages [7]; Ha and Kim reported that baicalein, a primary component of Scutellariae Radix, regulates the production of inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, and the expression of COX-2 mRNA, and it represses the microglial activity, suggesting that the flavonoid could be a good candidate for the therapy of central nervous system inflammation [8].