INS and juvenile idiopathic arthritis: Other transporters found are Slc19a1 (Figure 5(b)) which was reported also as a significant drug transporter, an important factor in response to methotrexate, a drug used for treatment of juvenile idiopathic arthritis [35], and Slc25a10 (Figure 5(c)), the mitochondrial malate and succinate carrier. Slc25a10 was previously shown to be essential for glucose stimulated insulin secretion (GSIS) [36].