Tumor infiltration by Foxp3+CD4+T cells, near-to-invariably detected by the immunohistochemical detection of Foxp3+ lymphocytes, has been associated with poor prognosis in cohorts of patients affected by multiple distinct neoplasms, includ-ing Hodgkin lymphoma, melanoma as well as breast, gastric and ovarian carcinoma [25, 28–31]. This evidence concerns the gene FOXP3 and melanoma.