The perspectives of the MPNs as “A Human Inflammation Model for Cancer Development” being driven by chronic inflammation in a self-perpetuating vicious circle from early cancer stage (ET/PV) to the advanced “metastatic” stage with severe MF and egress of CD34+ cells from bone marrow niches to the circulation (metastasis to the spleen and liver and elsewhere) are several [8–13, 96–103]. Here, CD34 is linked to cancer.