CD34 and cancer: In the context of matrix remodeling during cancer metastasis (which in MPNs consists of egress of CD34+ cells from the bone marrow niches into the circulation) it is of particular interest to note that IFN-inducible genes, including IFI27, have been shown to be associated with the so-called metagenes in patients with breast cancer, accurately identifying those patients with lymph node metastasis and accordingly predictors of outcomes in individual patients [94].