JAK1 and myelofibrosis: Thus, the perspectives may be that statins will achieve an important role in the future MPNs treatment in combination with JAK1/2 inhibitors and IFN-alpha2, a combination therapy, which—if instituted already from the time of diagnosis by potent inhibition of clonal proliferation and hence blockage of chronic inflammation generated by the malignant clone itself—may envisage the hope of reverting MPNs disease progression by inhibiting inflammation-driven genomic instability, subclone formation, mutagenesis, and thereby the ultimate transformation to myelofibrosis and acute myeloid leukemia.